Chemical constituents from the roots of Cynanchum paniculatum and their cytotoxic activity.
نویسندگان
چکیده
Two new steroidal saponins, cynanside A (1) and B (2) were isolated together with three known compounds (3-5) from the roots of Cynanchum paniculatum (Bunge) Kitag. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses, including extensive 2D NMR and acid hydrolysis. We evaluated the cytotoxicity of isolates (1-5) against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the SRB bioassay. Compounds 1 and 2 showed selective cytotoxicity against SK-MEL-2 cells with IC50 values of 26.55 and 17.36μM, respectively.
منابع مشابه
Biol. Pharm. Bull. 29(5) 971—975 (2006)
vacious plant distributed across all of Korea and also cultivated in China. The root of Cynanchum paniculatum is used as a Chinese traditional medicine. Recently, the plants of genus Cynanchum of Asclepiadaceae, e.g. Cynanchum atratum, Cynanchum auriculatum and Cynanchum paniculatum, were studied for their anticancer and analgesic effects. In addition, Cynanchum paniculatum has been traditional...
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ورودعنوان ژورنال:
- Carbohydrate research
دوره 381 شماره
صفحات -
تاریخ انتشار 2013